Is there Any Relationship Between Diabetic Gastroparesis and Mucosal İnjury?

Objective: We aimed to show the relationship between diabetic gastroparesis and mucosal injury by comparing the findings of upper gastrointestinal system endoscopy between patients with and without diabetic gastroparesis. Material and method: Upper gastrointestinal system endoscopy and gastric emptying scintigraphy were performed on the same day in 51 volunteer type 2 Diabetes Mellitus patients. 4-hour gastric emptying scintigraphy with 500 mCi Technetium (Tc) 99 m diethylene triamine pentaacetic acid (DTPA) in semisolid foods for the determination of gastroparesis was performed in the patients. Upper gastrointestinal system endoscopy was compared between patients with and without gastroparesis by gastric emptying scintigraphy. Results: The mean ages of patients with diabetic gastroparesis (20 Female (F)/10 Male (M)) and without (12F/9M) diabetic gastroparesis were 57.04 ± 9.41 and 53.35 ± 6.98 years, respectively. There was no statistically significant difference between groups in terms of age and gender distribution (p=0.192, p=0.489, respectively). There were no significant differences with respect to age, gender, body mass index (BMI), fasting blood glucose (FBG) and Hb A1c between groups (p=0.192, p=0.489, p=0.529, p=0.653, and p=0.707, respectively). Erosive (E) findings were more frequent in patients with (22 E/8 Nonerosive (NE)) than without (1 E/20 NE) diabetic gastroparesis, and the difference was statistically significant (p<0.05). Conclusion: Erosive findings were significantly more frequent in patients with than in those without diabetic gastroparesis. This also suggested that mucosal injury results from motility disorder.